The IKBKE Antibody from MyBioSource.com is a Mouse Monoclonal antibody to IKBKE, and IKK epsilon. This antibody recognizes Human antigen. The IKBKE Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Background: Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon.The transcription factor NFkappaB is retained in the cytoplasm in an inactive form by the inhibitory protein IkappaB. Activation of NFkappaB requires that IkappaB be phosphorylated on specific serine residues, which results in targeted degra-dation of IkappaB. IkappaB kinase alpha(IKKalpha), previously designated CHUK, interacts with IkappaB-alphaand specifically phosphorylates IkappaB-alphaon the sites that trigger its degradation, serines 32 and 36. The functional IKK complex contains three subunits, IKKalpha, IKKbetaand IKKgamma(also designated NEMO), and each appear to make essential contributions to IkappaB phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKKalphaand IKKbeta. IKK-i is pri-marily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFalpha, IL-1 and IL-6. Overexpression of IKK-i was shown to result in phosphorylation of IkappaBalphaon Ser32 and Ser36, and in NFkappaB activation, suggesting that IKK-i may act as an IkappaB kinase in the immune system